“Diagnostics and Monitoring of Oncological Diseases Using a Biomarker Panel” was the topic presented by the team from Petre Shotadze Tbilisi Medical Academy at the International Scientific Conference dedicated to the 150th anniversary of Ivane Javakhishvili’s birth. The event was held on April 23–24 at Ivane Javakhishvili Tbilisi State University. The report was delivered by Etuna Dumbadze, Manager of the TMA Laboratory. The presentation addressed current issues in molecular oncology, specifically the diagnostic potential of specific biomarkers for the detection and monitoring of tumor diseases, such as cancer-testis antigens (e.g., NY-ESO-1), PIWI proteins, and the tumor suppressor protein TP53. The research is focused on refining diagnostic panels and utilizing the enzyme-linked immunosorbent assay (ELISA) method, which aims to develop effective mechanisms for the management of oncological diseases in clinical practice.