Study of Nucleus Basalis of Meynert (NBM) role within memorising and learning processes on the behavioural, structural and molecular levels

Scientific Investigator: Gela Beselia Project Investigator: 2019-03-18 Project Duration: 9 months

Students are involved in the project realization.
Presented project aims to investigate different forms of memorising and learning processes among 2 groups of animals. Experimental group of animals, which will include subjects with immunotoxin induced damages of cholinergic and GABA-ergic neurones, will be compared to the control group of pseudo-operating subjects. Aside of it, project aims to identify changes, induced by the memory deficiency associated structural changes and neurotransmitter markers (cholinergic α7 nAChRs and M1 and glutamatergic GluN2B subunit containing NMDA receptor expression ) within the selected locations of cortical areas.  
Such multidisciplinary research on systematic, structural and molecular levels creates a prerequisite for obtaining new information regarding modulating functions of basal forebrain within memorising processes and enables us to determine causal relationship between forebrain, and function of internal networks in selected locations within the processes of memorising and learning.
Recognition of basal forebrain modulating mechanism on memory, as well as determining aspects of memory, where this system has high importance, would facilitate understanding of fundamental neurobiological mechanisms of the memory and elaborating new strategies for improvement of memory among patients with neurodegenerative diseases. Study of Nucleus Basalis of Meynert (NBM) role within memorising and learning processes on the behavioural, structural and molecular levels.