Evaluation of naturally occurring autoantibodies against hCG in patients with ovarian cysts

Scientific Investigator: Mariam Tevzadze Project Investigator: 2019-03-18 Project Duration: 12 months

Students are involved in the project realization.
The main aim of the project is to identify naturally occurring autoantibodies in the female patients with ovarian cysts during the reproductive ages. The first results of our experiments indicate that patients with ovarian cyst have significantly elevated levels of naturally occurring serum antibodies of IgG isotype against both hCG and hCGb, whilst patients with ovarian carcinoma expressed non appreciable levels of such antibodies. Based on this information we propose that naturally occurring autoantibodies have regulatory, protective role against the malignisation of ovarian cysts. We hope, that autoantibodies that have inhibitory or protecting effects could lead to the development of tumor prevention and treatment strategies. Evaluation of naturally occurring autoantibodies against hCG in patients with ovarian cysts.